Epidermolysis Bullosa (EB)... one of the most painful genetic diseases known to man. These children are referred to as the "butterfly children" because their skin is as gentle and delicate as a butterfly's wings! See what it's like to live with this condition:
A group of rare, painful, non-inflammatory blistering skin diseases that vary in severity from benign to life-threatening. They are caused by mutations in genes coding for proteins that normally anchor the epidermis to the dermis such as Keratin, Laminin, Integrins and Collagen. [Over 18 gene mutations have been described!]
Because of this genetic weakness, patients have skin that is “as fragile as a butterfly's wings” and develop painful blister formation from separation of the epidermis from the dermis.
The blisters often appear in response to minor injury, friction, heat, pressure, rubbing, or scratching. The blisters can also occur in the oral cavity, throat, vocal cords(horse cry), esophagus, and internal organs. Many cases will present at birth with skin blisters. They are similar to burn patients in terms of some of the treatment and complications.
Skin biopsy - Electron Microscopy (EM)
Important complications of the blisters include:
Dehydration and electrolyte imbalance from fluid loss
Malnutrition and anemia from bleeding.
Infections which may lead to sepsis and death.
Squamous cell carcinoma [Major cause of death in older patients]
Treatment: Daily wound care, bandaging, and pain management. Surveillance for skin cancer. There is no cure at this time.
Related article: Pathology of the Stars: America's Next Top Model
Which testicular tumor is DeadPool referring to in this movie clip?
Teratoma (Dermoid cyst) - Commonly contains teeth and hair! A testicle with teeth!!! Yikes!
Perhaps the same may be said of Pathologists!
Here's a fun way to remember the key facts about yolk sac tumor of the testes!
Read more: Yolk Sac Tumor Mnemonic
Ain't it the truth! This is a corollary of Murphy's law! So stay cool during the exam and always stick with your first answer!
The only exception is the small percentage of students, and you know who you are, whose first answer is always wrong - then go for the other one!!!!
Aphakia = Absence of the lens of the eye. It is usually due to surgical removal but may also be a congenital anomaly. Without a lens there is a loss of accommodation and hyperopia (farsightedness).
Retinal Tears often present with "flashes and floaters" and can lead to vision-threatening retinal detachment! Retinal tears are usually treated with laser surgery or cryotherapy (Cryopexy).
Got any good Ophthalmology jokes? Share them with me in the comment section!
Can you answer these 6 questions related to the cornea and it's diseases?
Read more: Pathology of the Cornea Quiz
A 68 year old male smoker with gradual bilateral visual loss as shown in the photo.
What's your diagnosis?
Read more: Ophthalmology Photo Quiz 1
Can you name the 4 most common "onions" in Medicine?
Read more: Most Common "Onions" in Medicine
Here's a way to use the name to remember the key features of Medullary Carcinoma of the thyroid:
Read more: Medullary Carcinoma Mnemonic
Here's a quick review and mnemonic for causes of Intrauterine Growth Restriction (IUGR):
Read more: Intrauterine Growth Restriction Mnemonic
Here's a fun way to remember some important facts about Henoch–Schönlein purpura:
Read more: Henoch–Schönlein Purpura Mnemonic
Here's a fun way to remember many of the important points about Basal Cell Carcinoma:
Read more: Basal Cell Carcinoma Mnemonic
Here's a quick review of dermatomyositis using the story of "Joe Millionaire":
Read more: Dermatomyositis
Here's a way to remember the important features of squamous cell carcinoma in-situ of the penis:
Read more: BaroneMnemonic: SCC In-situ lesions
Here's a fun way to remember the association of Dermatomyositis and polymyositis with the anti-JO-1 antibodies using the Singer Miley Cyrus and her ex-boyfriend Nick Jonas:
Read more: Barone Mnemonic: Dermatomyositis
Here's a simple way to remember the Kaposi Sarcoma virus for my Arabic friends:
Read more: Barone Mnemonic: Kaposi Sarcoma
Photo Courtesy of Dr. Daniel Breland
The definition of 'clubbing' changes after you go to medical school!
Read more: Med School Clubbing
Here's a great way to remember the important features of Langerhans Cell Histiocytosis by using the great tennis star Rafael Nadal!!!
Read more: Langerhans Cell Histiocytosis Mnemonic
Kisspeptin is a protein coded by the KISS1 gene and is produced in the arcuate nucleus. Kisspeptin stimulates the release of GnRH by the hypothalamus leading to the release of gonadotropins by the pituitary which stimulates the gonads resulting in puberty.
So it looks like KISS and Gene Simmons have been stimulating gonads and turning kids into adolescents for years!
Note: Kisspeptin was discover in Hershey, Pennsylvania which is the home of "Hershey's Kisses!"
Read more: Tennis Racket Pathology
Print it and post it on your Mirror!
Wing-beating tremor. Can you name the diagnosis?
Read more: Video Quiz #3
Read more: Guess who I am?
Here's an awesome animation showing all the key board facts for Cadmium Poisoning!:
Animations and Illustrations thanks to Dr. Cyrus Ghaedi.
Copyright ©2012 Thunderpath Media Inc.
Read more: BaroneMnemonic: Hydrocarbons
*Metabolic acidosis with an increased gap may occur due to production of lactic acid or hypoglycemia(ketones)
Download the Alcohol Poisoning CheatSheet!
Microcytic anemia with basophilic stipling
Ringed Sideroblasts on prussian blue stain.
The 2nd enzyme ALA-dehydratase and the final enzyme Ferrochelatase.
Acute tubular injury (ATI)
Stop the exposure!
Here's a sample of Dr. Raymon! This guy is awesome:
Read more: Tuberculosis by Dr Raymon
Here's a recent case from the wards to inspire you to become the best doctor that you can be. You will save lives and change the world for the better!! Can you make the diagnosis?
I'm one of your Kaplan students whom you taught in Newark NJ back in 2010. Currently I'm in my final year in internal medicine and will do hepatology next. The reason I'm sending you this message is to thank you for your valuable lectures. They were so awesome that not only helped me in Step 1 , 2, 3 but also helped me save a life...
I was in the MICU, on call, when I had this patient sent from the floor with severe altered mental status and she had been intubated so history out of the equation. I examined her and found asymmetric reflexes in the knees on the physical. During the rounds, the intern read the labs which were significant for a low platelet count and elevated creatinine. I was sitting beside the attending who was emphasizing on some point about the platelet count and the need for transfusion. She then asked the intern and me what do we think is the diagnosis?
Read more: Learn your Craft
What is a Fishbone Diagram and what is it used for?
Read more: Fishbone Diagram
Can you tell me why you get the different color changes of a bruise?
Read more: The Stages of a Contusion
Here's a fun way to remember the chromosome number for BRCA1:
Read more: BaroneMnemonic: BRCA1
Here are the distinguishing features of some of the most tested causes of Short stature (Dwarfism):
Read more: Short Stature
Here are the key points for this rare cause of short stature:
Read more: Psychosocial Dwarfism
The American College of Obstetricians and Gynecologists (ACOG) has decided to change the definition of Term pregnancy. Here is the new designations along with the former designation:
The reasoning behind the change is that:
Source: American College of Obstetricians and Gynecologists (ACOG)
Here's a visual way to remember the key associations for VHL:
Read more: BaroneMnemonic: VHL
Here's a way to remember some key facts about Hashimotos by using it's name!:
Read more: Hashimoto's Thyroiditis Mnemonic
Moonwalk your way to remembering the APGAR criteria.
Read more: APGAR Mnemonic
You'd be surprised how many people don't realize that.
Thanks to Dr. Thomas Cacciola from his Indeterminate Causality Blog.
Here's a fun way to remember the key associations for familial retinoblastoma :
Read more: Retinoblastoma Mnemonic
Here's a simple way to remember some important features of this autosomal recessive genetic disorder:
Read more: BaroneMnemonic: Abetalipoproteinemia
What's your guess?
Residency directors are less likely to look at your application if you have a failure on your first attempt of which board exam?
A) Step 1
B) Step 2 CK
Read more: Consequences
The name has the answer!
Here's a sample of my medical music! My 2nd song en Español!!! For my Latin Medical Mafia!
Thanks to Dr. Mandalyn Kautz
New version June 2, 2015!
An oldie but a goodie!
Source: "The Agnew Clinic," an 1889 oil painting by Thomas Eakin, shows a 19th century operating theater in action. (Image: Philadelphia Museum of Art/Public Domain)
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