“It all started with a Kiss!”
Kisspeptin is a protein coded by the KISS1 gene and is produced in the arcuate nucleus. Kisspeptin stimulates the release of GnRH by the hypothalamus leading to the release of gonadotropins by the pituitary which stimulates the gonads resulting in puberty.
So it looks like KISS and Gene Simmons have been stimulating gonads and turning kids into adolescents for years!
Note: Kisspeptin was discover in Hershey, Pennsylvania which is the home of "Hershey's Kisses!"