Progeria vs Werner Syndrome

Here's a comparison of Progeria and Werners syndrome which are both characterized by premature aging.

 

1 Most cases are new mutations since patients don’t typically live to reproductive age.

2 The farnesyl group fails to be removed and the abnormal protein interferes with the internal nuclear lamin leading to loss of structural support of the nucleus.

3 Farnesyltransferase Inhibitors are being used in clinical trials.

 

Formatting thanks to Dr. Britte Lowther.

 

Category: Genetics Mnemonics

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