Synovial Sarcoma Key Facts

  • Accounts for ~10% of soft tissue tumors
  • Most common in Young adults (20-40)
  • Most commonly occurs in the extremities near large joints (80% in the knees and ankles)
  • Classic t(X;18)(p11;q11) translocation
  • SYT-SSX gene fusion
  • Micro: Often has a biphasic histologic appearance containing both epithelial and spindle cell components
Category: Pathology Mnemonics

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